Tallink Spa & Conference hotel, Sadama 11a.
Lab-on-Chip Based Sensors
for bioparticles detection and characterisation
Abstract
Laboratory-on-Chip (LoC)
is an advanced multidisciplinary research approach calls for an integration of
heterogeneous structures including microelectronic and microfluidic
technologies as well as conventional biochemistry techniques. Standard CMOS
process is an excellent candidate to realize such LoC systems offering the
advantages of well-studied circuits and embedded sensors/actuators.
This tutorial presents
an overview of recent advances in the design and implementation of hybrid
microfluidic CMOS systems for LoC applications.
A CMOS-based LoC can be divided in three parts: microfluidic structure, biofunctionalized
layers (transduce the biological quantities to electrical changes or vice versa)
and microelectronic circuitry.
Through this technology
several embedded sensing techniques can be realized as reported in the
literature. In this tutorial, the optical, thermal, ISFET, impedimetric and in
particular capacitive sensors are presented for molecular/cellular
applications.
Outline:
13.00 Overview
13.10 Smart Medical Devices for Diagnostics Purpose
13.30 On-Chip microfluidic Packaging
13.50 Biofunctionalized Layers of CMOS chips
14.10 Coffee break
14.40 Biofunctionalized Layers of CMOS chips
a. Actuators (Magnetic, Electrical)
b. Sensors (Optical, Capacitive, ISFET, Thermal)
16.20 Direct-write CMOS based Lab-on-Chip
16.30 Summary
Sample publications by the Authors:
[1] SAWAN, M., GHAFAR-ZADEH, E., "A 0.18 μm CMOS Capacitive Detection Lab-on-Chip",
Invited Talk at IEEE-CICC, San Jose, September 2007.
[2] SAWAN, M., "Diagnostic tools based on mixed-technology microdevices",
Tutorial ECCDT2007, Sevilla, Spain, August 2007.
[3] GHAFAR-ZADEH, E., SAWAN, M., "Hybrid Microfluidic/CMOS Capacitive Sensor
Dedicated to Lab-on-Chip Applications",
IEEE Trans. on Biomedical Circuits & Systems, Dec. 2007.
[4] GHAFAR-ZADEH, E., SAWAN, M., THERRIAULT, D., "Novel Direct-Write CMOS-based
Laboratory-On-Chip: Design, Assembly and Experimental Results",
Elsevier Sensors & Actuators, Available online, 2006, 10 pages.
www.norchip.org
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Tel: +45 2212 5244, Fax: +45 4576 5708, E-mail: info@norchip.org
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